OptimalGoldstandardDesigns

Methods to calculate optimal design parameters for one- and two-stage three-arm group-sequential gold-standard non-inferiority trial designs with or without binding or nonbinding futility boundaries, as described in (Meis et al. 2023) .

References

Meis J, Pilz M, Herrmann C, Bokelmann B, Rauch G, Kieser M (2023). “Optimization of the two-stage group sequential three-arm gold-standard design for non-inferiority trials.” Statistics in Medicine, 42(4), 536-558. doi:10.1002/sim.9630 .

See also

Useful links:

• https://github.com/jan-imbi/OptimalGoldstandardDesigns

Author

Maintainer: Jan Meis meis@imbi.uni-heidelberg.de (ORCID)